PAI-1 Gene Polymorphism
Diagnostic Lab Test:
- Plasminogen Activator Inhibitor-1 (PAI-1) Gene Polymorphism
Plasminogen Activator Inhibitor-1 (PAI-1) Gene Polymorphism refers to variations in the gene that encodes the PAI-1 protein, a key regulator of the fibrinolytic system. The PAI-1 gene, officially known as SERPINE1, is responsible for producing the PAI-1 protein, which inhibits tissue plasminogen activator (tPA) and urokinase (uPA), enzymes critical for breaking down blood clots. Polymorphisms in the PAI-1 gene can influence the expression levels and activity of the PAI-1 protein, thereby affecting an individual’s propensity for thrombotic events and various other health conditions. Analyzing PAI-1 gene polymorphisms provides valuable insights into genetic predispositions related to cardiovascular health, metabolic disorders, and other systemic conditions.
Certain polymorphisms in the PAI-1 gene, such as the 4G/5G variant, are associated with altered PAI-1 levels. The 4G allele is linked to higher PAI-1 expression, increasing the risk of thrombotic events like myocardial infarction, stroke, and peripheral artery disease by promoting a prothrombotic state.
This genetic test offers critical insights into an individual’s predisposition to thrombotic, cardiovascular, and metabolic diseases.
Pairs well with
PAI-1 Gene Polymorphism
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How it works
Purchase your tests
Purchase this test and any other tests you'd like online. A healthcare provider will review and approve your test requests; no healthcare provider visit is required.
Provide your sample
Visit a Labcorp location near you for sample collection. Use our Labcorp locator below to find a location near you.
Get your results
Our partnered facilities will process your bloodwork. Lab Results typically arrive within 14 business days, and we will email them to you as soon as they arrive.
Lab work FAQs
Please read our FAQs page to find out more.
How quickly will my lab results arrive?
Your lab results will typically arrive within two weeks, though processing time may vary based on the size and complexity of your panel. Rest assured, once your results are ready, they will be securely delivered to your email. No waiting rooms. No chasing paperwork. Just precision diagnostics at your fingertips.
Does Marek Diagnostics accept insurance?
Marek Diagnostics is a cash-pay service. Our platform offers direct access to comprehensive testing without the limitations, denials, or delays imposed by insurance companies. If traditional insurance covered the kind of proactive, high-quality lab work we offer, Marek Diagnostics wouldn’t need to exist.
However, many clients successfully use their HSA/FSA to cover their testing costs. Marek Diagnostics is partnered with TrueMed for convenient deployment of HSA/FSA funds at checkout.
My panel Meets Treatment Requirements — what does that mean?
Marek Diagnostics is an extension of Marek Health, the leading health optimization platform designed to turn your results into informed action.
If your panel Meets Treatment Requirements, you’re eligible to enroll into Guided Optimization, an exclusive program that connects you with:
- Detailed, expert led lab analysis
- A consultation with a Marek Health coach and board-certified medical provider
- A precision health optimization plan
- Access to high-quality treatment options
If you’re unsure what to do with your results, Marek Health is the bridge between lab results and achieving your goals.
Do I need to pay a separate fee at the lab to get my blood drawn?
No additional payment is required at the lab. Our expert-built panels include the venipuncture and if you’re building a custom panel or testing biomarkers individually, a $5 venipuncture fee will be automatically added at checkout.