Celiac Disease Antibody Profile (tTG IgA, tTG IgG, DGP IgA, DGP IgG, EMA IgA, Total IgA)
Diagnostic Blood Test:
- Celiac Antibodies Profile:
- tTG IgA
- tTG IgG
- DGP IgA
- DGP IgG
- EMA IgA
- Total IgA
The Celiac Antibodies Profile is a comprehensive blood test designed to detect specific antibodies associated with celiac disease, an autoimmune disorder triggered by the ingestion of gluten. This profile includes measurements of various immunoglobulins that target components of gluten and the intestinal lining, aiding in the accurate diagnosis and management of celiac disease. Early detection through this profile is crucial for preventing long-term complications and improving the quality of life for affected individuals.
Components of the Celiac Antibodies Profile:
-
tTG IgA (Tissue Transglutaminase IgA):
- Measures Immunoglobulin A (IgA) antibodies against tissue transglutaminase, an enzyme involved in the modification of gluten peptides. Elevated tTG IgA levels are highly specific for celiac disease and are considered the primary screening test. High levels indicate an autoimmune response against the intestinal lining triggered by gluten ingestion.
-
tTG IgG (Tissue Transglutaminase IgG):
- Assesses Immunoglobulin G (IgG) antibodies against tissue transglutaminase. Useful in individuals with selective IgA deficiency, a condition more common in celiac patients. Elevated tTG IgG levels support the diagnosis of celiac disease when IgA-based tests are inconclusive.
-
DGP IgA (Deamidated Gliadin Peptide IgA):
- Measures IgA antibodies against deamidated gliadin peptides, which are gluten-derived proteins. DGP IgA is sensitive in detecting celiac disease, especially in young children and in cases where tTG IgA levels are borderline. It complements tTG IgA in enhancing diagnostic accuracy.
-
DGP IgG (Deamidated Gliadin Peptide IgG):
- Evaluates IgG antibodies against deamidated gliadin peptides. Similar to DGP IgA, DGP IgG is valuable in patients with IgA deficiency. Elevated levels indicate an immune response to gluten, supporting the diagnosis of celiac disease.
-
EMA IgA (Endomysial Antibody IgA):
- Detects IgA antibodies against endomysium, the connective tissue surrounding muscle fibers.EMA IgA has high specificity for celiac disease and is often used as a confirmatory test following positive tTG IgA results. Positive EMA IgA strongly suggests celiac disease.
-
Total IgA:
- Measures the overall level of Immunoglobulin A in the blood – essential for identifying IgA deficiency, which can lead to false-negative results in IgA-based celiac antibody tests. Normal or elevated total IgA levels ensure the reliability of IgA-based assays.
The Celiac Antibodies Profile is instrumental in diagnosing celiac disease by identifying specific antibody responses to gluten ingestion. Elevated levels of tTG IgA, DGP IgA, and EMA IgA are strong indicators of the disease.
Pairs well with
Celiac Disease Antibody Profile (tTG IgA, tTG IgG, DGP IgA, DGP IgG, EMA IgA, Total IgA)
If you have any questions, you are always welcome to contact us. We'll get back to you as soon as possible, within 24 hours on weekdays.
-
Shipping Information
Use this text to answer questions in as much detail as possible for your customers.
-
Customer Support
Use this text to answer questions in as much detail as possible for your customers.
-
FAQ’s
Use this text to answer questions in as much detail as possible for your customers.
-
Contact Us
Use this text to answer questions in as much detail as possible for your customers.
How it works
Purchase your tests
Purchase this test and any other tests you'd like online. A healthcare provider will review and approve your test requests; no healthcare provider visit is required.
Provide your sample
Visit a Labcorp location near you for sample collection. Use our Labcorp locator below to find a location near you.
Get your results
Our partnered facilities will process your bloodwork. Lab Results typically arrive within 14 business days, and we will email them to you as soon as they arrive.
Lab work FAQs
Please read our FAQs page to find out more.
How quickly will my lab results arrive?
Your lab results will typically arrive within two weeks, though processing time may vary based on the size and complexity of your panel. Rest assured, once your results are ready, they will be securely delivered to your email. No waiting rooms. No chasing paperwork. Just precision diagnostics at your fingertips.
Does Marek Diagnostics accept insurance?
Marek Diagnostics is a cash-pay service. Our platform offers direct access to comprehensive testing without the limitations, denials, or delays imposed by insurance companies. If traditional insurance covered the kind of proactive, high-quality lab work we offer, Marek Diagnostics wouldn’t need to exist.
However, many clients successfully use their HSA/FSA to cover their testing costs. Marek Diagnostics is partnered with TrueMed for convenient deployment of HSA/FSA funds at checkout.
My panel Meets Treatment Requirements — what does that mean?
Marek Diagnostics is an extension of Marek Health, the leading health optimization platform designed to turn your results into informed action.
If your panel Meets Treatment Requirements, you’re eligible to enroll into Guided Optimization, an exclusive program that connects you with:
- Detailed, expert led lab analysis
- A consultation with a Marek Health coach and board-certified medical provider
- A precision health optimization plan
- Access to high-quality treatment options
If you’re unsure what to do with your results, Marek Health is the bridge between lab results and achieving your goals.
Do I need to pay a separate fee at the lab to get my blood drawn?
No additional payment is required at the lab. Our expert-built panels include the venipuncture and if you’re building a custom panel or testing biomarkers individually, a $5 venipuncture fee will be automatically added at checkout.