Diagnostic Blood Test:

• Asymmetric dimethylarginine (ADMA)
• Symmetric dimethylarginine (SDMA)

Asymmetric dimethylarginine (ADMA) is a naturally occurring by-product of protein methylation. ADMA reduces your body's ability to produce nitric oxide, a molecure that helps maintain a healthy endothelium. Hence, elevations in ADMA may increase risk of cardiovsacular disease, erectile dysfunction and kidney disease. Moreover, elevations in ADMA are significantly associated with atherosclerosis. ADMA levels become elevated in the presence of high LDL cholesterol and homocysteine.

Symmetric dimethylarginine (SDMA) is an isomer of ADMA (Asymmetric dimethylarginine) and a valuable marker of kidney function. Unlike creatinine, SDMA is exclusively eliminated by the kidneys, making it a more specific indicator of renal function. Elevated SDMA levels in the blood are associated with reduced kidney function and can indicate the early stages of kidney disease, often before traditional markers like creatinine become abnormal. Monitoring SDMA is essential for the early detection and management of chronic kidney disease, allowing for timely intervention to preserve kidney health and overall metabolic balance.